Palavras-chave
Alimentos funcionais
Superfrutas
Como Citar
Resumo
O Brasil é o país com maior biodiversidade no mundo. Dentro dos seus diferentes biomas, há grande variedade de frutas com potencial benéfico para a saúde. As “superfrutas” são assim denominadas porque possuem um grande potencial terapêutico com grande concentração de compostos bioativos como fitoquímicos e/ou ácidos graxos e/ou vitaminas e/ou minerais. O objetivo do presente trabalho foi apresentar o açaí, uma superfruta nativa brasileira, com enfoque em suas diferentes aplicações e o potencial biológico dessa espécie correlacionando com seus componentes fitoquímicos. Para tanto, foi realizado um estudo sistemático direcionado para a fruta-alvo da pesquisa utilizando a base de dado PubMed. Como critério de inclusão foram utilizados artigos científicos com data de publicação entre 2013 e 2023, com acesso completo ao texto nos idiomas inglês e português. Dentro deste panorama concluiu-se que a superfruta do estudo possui uma ampla variedade de fitoquímicos, os quais se destacam as antocianinas, flavonoides e ácidos fenólicos, sendo estes responsáveis por inúmeras atividades biológicas como potencial antioxidante, anti-inflamatório, anticancerígeno e neuroprotetora. Além disso, o fruto tem demonstrado grande potencial para as indústrias alimentícias como fonte de matéria-prima para inovação de produtos funcionais. Entretanto, os estudos revisados demonstram a necessidade da realização de mais ensaios clínicos que comprovem seus benefícios em seres humanos, busca contínua por novas tecnologias que visem melhorar a preservação de seus compostos e investigações de novas formulações para produtos funcionais que permitam o total aproveitamento dessa superfruta nativa brasileira.
Referências
ABE SATO, S. T. et al. Isolation and Genetic Identification of Endophytic Lactic Acid Bacteria From the Amazonian Açai Fruits: probiotics features of selected strains and their potential to inhibit pathogens. Frontiers in microbiology. 2021 Jan. 8; 11:610524. doi: 10.3389/fmicb.2020.610524. PMID: 33488551; PMCID: PMC7819895. Disponível em: https://pubmed.ncbi.nlm.nih.gov/33488551/#full-view-affiliation-1. Acesso em: 1 jul. 2024.
ALESSANDRA-PERINI, J. et al. Euterpe oleracea Extract (Açaí) Exhibits Cardioprotective Effects After Chemotherapy Treatment in a Breast Cancer Model. BMC Complementary Medicine and Therapies. 2023 Aug. 25;23(1):301. doi: 10.1186/s12906-023-04104-7. PMID: 37626388; PMCID: PMC10463785. Disponível em: https://pubmed.ncbi.nlm.nih.gov/37626388/#full-view-affiliation-3. Acesso em: 1 jul. 2024.
BELLUCCI, E. R. B. et al. Açaí Extract Powder As Natural Antioxidant on Pork Patties During the Refrigerated Storage. Meat Science. 2022 Feb.; 184:108667. doi: 10.1016/j.meatsci.2021.108667. Epub 2021 Sep. 4. PMID: 34656002. Disponível em: ttps://pubmed.ncbi.nlm.nih.gov/34656002/.
Acesso em: 1 jul. 2024.
BRITO, L. L. et al. Effects of Euterpe oleracea Mart. Extract on Candida spp. Biofilms. Brazilian Journal of Microbiology. 2023 Mar.; 54(1):29-36. doi: 10.1007/s42770-023-00919-1. Epub 2023 Feb. 7. PMID: 36746872; PMCID: PMC9944593. Disponível em: https://pubmed.ncbi.nlm.nih.gov/36746872/. Acesso em: 1 jul. 2024.
CESAR, L. T. et al. Effects of Clarification on Physicochemical Characteristics, Antioxidant Capacity and Quality Attributes of Açaí (Euterpe oleracea Mart.) Juice. Journal of Food Science and Technology. 2014 Nov.; 51(11):3293-300. doi: 10.1007/s13197-012-0809-6. Epub
Sep. 16. PMID: 26396323; PMCID: PMC4571208. Disponível em: https://pubmed.ncbi.nlm.nih.gov/26396323/. Acesso em: 1 jul. 2024.
ČIŽAUSKAITE, U. et al. Natural Ingredients-Based Gummy Bear Composition Designed According to Texture Analysis and Sensory Evaluation In Vivo. Molecules. 2019 Apr. 11; 24(7):1442. doi: 10.3390/molecules24071442. PMID: 30979093; PMCID: PMC6480394. Disponível em: https://pubmed.ncbi.nlm.nih.gov/30979093/. Acesso em: 1 jul. 2024.
COSTA, H. C. B. et al. Study of Rheological Properties of Açai Berry Pulp: an analysis of its time-dependent behavior and the effect of temperature. Journal of biological physics. 2018 Dec.; 44(4):557-577. doi: 10.1007/s10867-018-9506-7. Epub 2018 June 26. PMID: 29946928; PMCID: PMC6208591. Disponível em: https://pubmed.ncbi.nlm.nih.gov/29946928/ Acesso em: 1 jul. 2024.
COSTA, H. C. DE B. et al. Effect of Microwave-assisted Processing on Polyphenol Oxidase and Peroxidase Inactivation Kinetics of Açai-berry (Euterpe oleracea) Pulp. Food Chemistry.
Mar. 30; 341(Pt 2):128287. doi: 10.1016/j.foodchem.2020.128287. Epub 2020 Oct. 2. PMID: 33059272. Disponível em: https://pubmed.ncbi.nlm.nih.gov/33059272/ Acesso em: 1 jul. 2024.
COSTA, R. et al. Antiangiogenic and Antioxidant in Vitro Properties of Hydroethanolic Extract from Açaí (Euterpe oleracea) Dietary Powder Supplement. Molecules. 2021 Apr. 1; 26(7):2011. doi: 10.3390/molecules26072011. PMID: 33916166; PMCID: PMC8036632. Disponível em: https://pubmed.ncbi.nlm.nih.gov/33916166/ Acesso em: 1 jul. 2024.
D’AMICO, R. et al. Açai Berry Mitigates Parkinson’s Disease Progression Showing Dopaminergic Neuroprotection via Nrf2-HO1 Pathways. Molecular Neurobiology. 2022 Oct.; 59(10):6519-6533. doi: 10.1007/s12035-022-02982-5. Epub 2022 Aug. 15. PMID: 35970975; PMCID: PMC9463222. Disponível em: https://pubmed.ncbi.nlm.nih.gov/35970975/. Acesso em: 1 jul. 2024.
DE ARAÚJO, F. F. et al. Polyphenols and their Applications: an approach in food chemistry and innovation potential. Food chemistry.
Feb. 15; 338:127535. doi: 10.1016/j.foodchem.2020.127535. Epub 2020 July 9. PMID: 32798817. Disponível em: https://pubmed.ncbi.nlm.nih.gov/32798817/. Acesso em: 1 jul. 2024.
DE BEM, G. F. et al. Antidiabetic Effect of Euterpe oleracea Mart. (Açaí) Extract and Exercise Training on High-fat Diet and Streptozotocin-induced Diabetic Rats: a positive interaction. PLoS ONE. 2018 June 19; 13(6):e0199207. doi: 10.1371/journal.pone.0199207. PMID: 29920546; PMCID: PMC6007924. Disponível em: https://pubmed.ncbi.nlm.nih.gov/29920546/. Acesso: 1 jul. 2024.
DE FREITAS CARVALHO, M. M. et al. Effects of Açai on Oxidative Stress, ER Stress, and Inflammation-related Parameters in Mice With High Fat Diet-fed Induced NAFLD. Scientific Reports. 2019 May 30; 9(1):8107. doi: 10.1038/s41598-019-44563-y. PMID: 31147590; PMCID: PMC6542795. Disponível em: https://pubmed.ncbi.nlm.nih.gov/31147590/. Acesso em: 1 jul. 2024.
DE OLIVEIRA, P. R. B. et al. Euterpe oleracea Mart.-derived polyphenols protect mice from diet-induced obesity and fatty liver by regulating hepatic lipogenesis and cholesterol excretion. PLoS ONE. 2015 Dec. 2; 10(12):e0143721. doi: 10.1371/journal.pone.0143721. PMID: 26630290; PMCID: PMC4668108. Disponível em: https://pubmed.ncbi.nlm.nih.gov/26630290/. Acesso em: 1 jul. 2024.
DE SOUZA SILVA, A. P. et al. Phenolic Profile and the Antioxidant, Anti-Inflammatory, and Antimicrobial Properties of Açaí (Euterpe oleracea) Meal: a prospective study. Foods.
Dec. 24; 12(1):86. doi: 10.3390/foods12010086. PMID: 36613302; PMCID: PMC9818655. Disponível em: https://pubmed.ncbi.nlm.nih.gov/36613302/. Acesso em: 1 jul. 2024.
DO NASCIMENTO, V. H. N. et al. Antioxidant Effects of Açaí Seed (Euterpe oleracea) in Anorexia-cachexia Syndrome Induced by Walker-256 Tumor. Acta Cirúrgica Brasileira. 2016 Sep.; 31(9):597-601. doi: 10.1590/S0102-865020160090000004. PMID: 27737344. Disponível em: https://pubmed.ncbi.nlm.nih.gov/27737344/. Acesso em: 1 jul. 2024.
FELZENSZWALB, I. et al. Toxicological Evaluation of Euterpe edulis: a potential superfruit to be considered. Food and Chemical Toxicology. 2013 Aug.; 58:536-44. doi: 10.1016/j.fct.2013.05.029. Epub 2013 May 24. PMID: 23712094. Disponível em: https://pubmed.ncbi.nlm.nih.gov/23712094/. Acesso em: 1 jul. 2024.
FERREIRA, L. T. et al. Chemical Genomic Profiling Unveils the in vitro and in vivo Antiplasmodial Mechanism of Açaĺ (Euterpe oleracea Mart.) Polyphenols. ACS Omega. 2019 Sep. 13; 4(13):15628-15635. doi: 10.1021/acsomega.9b02127. PMID: 31572864; PMCID: PMC6761757. Disponível em: https://pubmed.ncbi.nlm.nih.gov/31572864/. Acesso em: 1 jul. 2024.
FIGUEIREDO, A. M. et al. Açai Supplementation (Euterpe oleracea Mart.) Attenuates Cardiac Remodeling After Myocardial Infarction in Rats Through Different Mechanistic Pathways. PLoS ONE. 2022 Mar. 4; 17(3):e0264854. doi: 10.1371/journal.pone.0264854. PMID: 35245316; PMCID: PMC8896726. Disponível em: https://pubmed.ncbi.nlm.nih.gov/35245316/. Acesso: 1 jul. 2024.
FILHO, W. E. M. et al. Antitumor Effect of Açaí (Euterpe oleracea Mart.) Seed Extract in LNCaP Cells and in the Solid Ehrlich Carcinoma Model. Cancers (Basel). 2023 Apr. 28; 15(9):2544. doi: 10.3390/cancers15092544. PMID: 37174010; PMCID: PMC10177358. Disponível em: https://pubmed.ncbi.nlm.nih.gov/37174010/. Acesso em: 1 jul. 2024.
GARCIA-VALLEJO, M. C.; POVEDA-GIRALDO, J. A.; CARDONA ALZATE, C. A. Valorization Alternatives of Tropical Forest Fruits Based on the Açai (Euterpe oleracea) Processing in Small Communities. Foods. 2023 June 1; 12(11):2229. doi: 10.3390/foods12112229. PMID: 37297474; PMCID: PMC10253147. Disponível em: https://pubmed.ncbi.nlm.nih.gov/37297474/. Acesso em: 1 jul. 2024.
GENOVESE, T. et al. Açaí (Euterpe oleracea Mart.) Seeds Regulate NF-κB and Nrf2/ARE Pathways Protecting Lung against Acute and Chronic Inflammation. Cellular Physiology and Biochemistry. 2022 May 13; 56(S2):1-20. doi: 10.33594/000000529. PMID: 35551733. Disponível em: https://pubmed.ncbi.nlm.nih.gov/35551733/. Acesso em: 1 jul. 2024.
HECK, K. L. et al. Standardization of Açaí Extracts for in-vitro Assays Based on Anthocyanin Quantitation. Journal Of Food Composition And Analysis. 2023 May; 118:105155. doi: 10.1016/j.jfca.2023.105155. Epub 2023 Jan. 19. PMID: 36844472; PMCID: PMC9957365. Disponível em: https://pubmed.ncbi.nlm.nih.gov/36844472/. Acesso em: 1 jul. 2024.
IGREJA, W. S. et al. Açai Seeds (Euterpe oleracea Mart) are Agroindustrial Waste with High Potential to Produce Low-Cost Substrates after Acid Hydrolysis. Molecules. 2023 Sep. 16; 28(18):6661. doi: 10.3390/molecules28186661. PMID: 37764435; PMCID: PMC10536898. Disponível em: https://pubmed.ncbi.nlm.nih.gov/37764435/. Acesso em: 1 jul. 2024.
IMPELLIZZERI, D. et al. Açai Berry Mitigates Vascular Dementia-Induced Neuropathological Alterations Modulating Nrf-2/Beclin1 Pathways. Cells. 2022 Aug. 22; 11(16):2616. doi: 10.3390/cells11162616. PMID: 36010690; PMCID: PMC9406985. Disponível em: https://pubmed.ncbi.nlm.nih.gov/36010690/. Acesso em: 1 jul. 2024.
INTERDONATO, L. et al. Açai Berry Administration Promotes Wound Healing through Wnt/β-Catenin Pathway. Int J Mol Sci. 2023 Jan. 3; 24(1):834. doi: 10.3390/ijms24010834. PMID: 36614291; PMCID: PMC9821151. Disponível em: https://pubmed.ncbi.nlm.nih.gov/36614291/. Acesso em: 1 jul. 2024.
JARAMILLO, J. E. C. C. et al. Impact of the mode of Extraction on the Lipidomic Profile of Oils Obtained from Selected Amazonian Fruits. Biomolecules. 2019 Aug. 1; 9(8):329. doi: 10.3390/biom9080329. PMID: 31374835; PMCID: PMC6722717. Disponível em: https://pubmed.ncbi.nlm.nih.gov/31374835/. Acesso em: 1 jul. 2024.
JESUS, A. L. T. DE; LEITE, T. S.; CRISTIANINI, M. High Isostatic Pressure and Thermal Processing of Açaí Fruit (Euterpe oleracea Martius): effect on pulp color and inactivation of peroxidase and polyphenol oxidase. Food Res Int. 2018 Mar.; 105:853-862. doi: 10.1016/j.foodres.2017.12.013. Epub 2017 Dec. 11. PMID: 29433282. Disponível em: https://pubmed.ncbi.nlm.nih.gov/29433282/. Acesso em: 1 jul. 2024.
KANDAGATLA, S. K. et al. Pheophorbide Derivatives Isolated from Açaí Berries (Euterpea oleracea) Activate an Antioxidant Response Element in vitro. Nat Prod Commun. 2019 June; 14(6):10.1177/1934578x19852443. doi: 10.1177/1934578X19852443. Epub 2019 June 6. PMID: 33214801; PMCID: PMC7673296. Disponível em: https://pubmed.ncbi.nlm.nih.gov/33214801/. Acesso em: 1 jul. 2024.
KUMAR, A. et al. Major Phytochemicals: recent advances in health benefits and extraction method. Molecules. 2023 Jan. 16;28(2):887. doi: 10.3390/molecules28020887. PMID: 36677944; PMCID: PMC9862941. Disponível em: https://pubmed.ncbi.nlm.nih.gov/36677944/. Acesso em: 1 jul. 2024.
LAURINDO, L. F. et al. Açaí (Euterpe oleracea Mart.) in Health and Disease: a critical review. Nutrients. 2023 Feb. 16; 15(4):989. doi: 10.3390/nu15040989. PMID: 36839349; PMCID: PMC9965320. Disponível em: https://pubmed.ncbi.nlm.nih.gov/36839349/. Acesso em: 1 jul. 2024.
LIMA, H. et al. Use of Agroindustrial Wastes (Açai Fiber and Glycerol) in the Preparation of Cookies. J Food Sci Technol. 2015 Jul.; 52(7):4593-9. doi: 10.1007/s13197-014-1493-5. Epub 2014 Oct. 17. PMID: 26139930; PMCID: PMC4486562. Disponível em: https://pubmed.ncbi.nlm.nih.gov/26139930/. Acesso em: 1 jul. 2024.
LINHARES, M. DE F. D. et al. Thermal and Non-thermal Processing Effect on Açai Juice Composition. Food Res Int. 2020 Oct.; 136:109506. doi: 10.1016/j.foodres.2020.109506. Epub 2020 July 3. PMID: 32846584. Disponível em: https://pubmed.ncbi.nlm.nih.gov/32846584/. Acesso em: 1 jul. 2024.
LIU, J. et al. Superfruits in China: Bioactive Phytochemicals and their Potential Health Benefits – a review. Food Sci Nutr. 2021 Oct. 3; 9(12):6892-6902. doi: 10.1002/fsn3.2614. PMID: 34925817; PMCID: PMC8645738. Disponível em: https://pubmed.ncbi.nlm.nih.gov/34925817/. Acesso em: 1 jul. 2024.
LIU, W.-Y. et al. Preparation, Characterization, Identification, and Antioxidant Properties of Fermented Acaí (Euterpe oleracea). Food Sci Nutr. 2023 Feb. 28; 11(6):2925-2941. doi: 10.1002/fsn3.3274. PMID: 37324839; PMCID: PMC10261820. Disponível em: https://pubmed.ncbi.nlm.nih.gov/37324839/. Acesso em: 1 jul. 20024.
LÓPEZ DE DICASTILLO, C. et al. Enhancing Thermal Stability and Bioaccesibility of Açaí Fruit Polyphenols through Electrohydrodynamic Encapsulation into Zein Electrosprayed Particles. Antioxidants (Basel). 2019 Oct. 9;8(10):464. doi: 10.3390/antiox8100464. PMID: 31600875; PMCID: PMC6826472. Disponível em: https://pubmed.ncbi.nlm.nih.gov/31600875/. Acesso em: 1 jul. 2024.
MACHADO, A. K. et al. Neuroprotective Effects of Açaí (Euterpe oleracea Mart.) against Rotenone in Vitro Exposure. Oxidative Medicine and Cellular Longevity. 2016; 2016:8940850. doi: 10.1155/2016/8940850. Epub 2016 Oct. 3. PMID: 27781077; PMCID: PMC5066013. Disponível em: https://pubmed.ncbi.nlm.nih.gov/27781077/. Acesso em: 1 jul. 2024.
MACHADO, D. E. et al. Euterpe oleracea Extract (Açaí) is a Promising Novel Pharmacological Therapeutic Treatment for Experimental Endometriosis. PLoS One. 2016 Nov. 16; 11(11):e0166059. doi: 10.1371/journal.pone.0166059. PMID: 27851787; PMCID: PMC5113045. Disponível em: https://pubmed.ncbi.nlm.nih.gov/27851787/. Acesso em: 1 jul. 2024.
MACIEL-SILVA, F. W. et al. Pressurized Liquid Extraction Coupled in-line with SPE and on-line with HPLC (PLE-SPExHPLC) for the Recovery and Purification of Anthocyanins from SC-CO2 Semi-defatted Açaí (Euterpe oleracea). Food Res Int. 2022 Oct.; 160:111711. doi: 10.1016/j.foodres.2022.111711. Epub 2022 July 20. PMID: 36076407. Disponível em: https://pubmed.ncbi.nlm.nih.gov/36076407/. Acesso em: 1 jul. 2024.
MAGALHÃES, T. S. S. DE A. et al. The Use of Euterpe oleracea Mart. As a New Perspective for Disease Treatment and Prevention. Biomolecules. 2020 May 26; 10(6):813. doi: 10.3390/biom10060813. PMID: 32466439; PMCID: PMC7356995. Disponível em: https://pubmed.ncbi.nlm.nih.gov/32466439/. Acesso em: 1 jul. 2024.
MANICA-CATTANI, M. F. et al. Amazonian Fruits with Potential Effects on COVID-19 by Inflammaging Modulation: a narrative review.
J Food Biochem. 2022 Dec.; 46(12):e14472. doi: 10.1111/jfbc.14472. Epub 2022 Oct. 14. PMID: 36240164; PMCID: PMC9874877. Disponível em: https://pubmed.ncbi.nlm.nih.gov/36240164/. Acesso em: 1 jul. 2024.
MARTINS, G. R. et al. Açaí (Euterpe oleracea Mart.) Seed Extracts from Different Varieties: a source of proanthocyanidins and eco-friendly corrosion inhibition activity. Molecules. 2021 June 5; 26(11):3433. doi: 10.3390/molecules26113433. PMID: 34198881; PMCID: PMC8201347. Disponível em: https://pubmed.ncbi.nlm.nih.gov/34198881/. Acesso em: 1 jul. 2024.
MARTINS, G. R. et al. A Validated Folin-Ciocalteu Method for Total Phenolics Quantification of Condensed Tannin-rich Açaí (Euterpe oleracea Mart.) Seeds Extract. J Food Sci Technol. 2021 Dec.; 58(12):4693-4702. doi: 10.1007/s13197-020-04959-5. Epub 2021 Jan. 18. PMID: 34629533; PMCID: PMC8479047. Disponível em: https://pubmed.ncbi.nlm.nih.gov/34629533/. Acesso em: 1 jul. 2024.
MELO, P. S. et al. Simulated Gastrointestinal Digestion of Brazilian Açaí Seeds Affects the Content of Flavan-3-ol Derivatives, and their Antioxidant and Anti-inflammatory Activities. Heliyon. 2020 Oct. 13; 6(10):e05214. doi: 10.1016/j.heliyon.2020.e05214. PMID: 33088966; PMCID: PMC7566108. Disponível em: https://pubmed.ncbi.nlm.nih.gov/33088966/. Acesso em: 1 jul. 2024.
MORAIS, R. A. et al. Nutritional Composition and Bioactive Compounds of Native Brazilian Fruits of the Arecaceae Family and its Potential Applications for Health Promotion. Molecules. 2018 Nov. 18; 23(11):3015. doi: 10.3390/molecules23113015. PMID: 30453683; PMCID: PMC6278552. Disponível em: https://pubmed.ncbi.nlm.nih.gov/30453683/. Disponível em: 1 jul. 2024.
PÉREZ, M. M. et al. Production of Omegas-6 and 9 from the Hydrolysis of Açaí and Buriti Oils by Lipase immobilized on a Hydrophobic Support. Molecules. 2018 Nov. 18; 23(11):3015. doi: 10.3390/molecules23113015. PMID: 30453683; PMCID: PMC6278552. Disponível em: https://pubmed.ncbi.nlm.nih.gov/30453683/. Acesso em: 1 jul. 2024.
SADOWSKA-KRĘPA, E. et al. Effects of Supplementation with Acai (Euterpe oleracea Mart.) Berry-based Juice Blend on the Blood Antioxidant Defence Capacity and Lipid Profile in Junior Hurdlers. A pilot study. Biol Sport. 2015 June; 32(2):161-8. doi: 10.5604/20831862.1144419. Epub 2015 Mar. 15. PMID: 26060341; PMCID: PMC4447763. Disponível em: https://pubmed.ncbi.nlm.nih.gov/26060341/. Acesso em: 1 jul.2024.
SHEN, J. et al. Dietary Phytochemicals that can Extend Longevity by Regulation of Metabolism. Plant Foods Hum Nutr. 2022 Mar.; 77(1):12-19. doi: 10.1007/s11130-021-00946-z. Epub 2022 Jan. 13. PMID: 35025006; PMCID: PMC8756168. Disponível em: https://pubmed.ncbi.nlm.nih.gov/35025006/. Acesso em: 1 jul. 2024.
SILVA, D. F. et al. Acai (Euterpe oleracea Mart) Consumption and Prevention of Chronic Diseases: is there an association? A preliminary study. Scientific World Journal. 2020 June 1;2020:5782485. doi: 10.1155/2020/5782485. PMID: 32565751; PMCID: PMC7285393. Disponível em: https://pubmed.ncbi.nlm.nih.gov/32565751/. Acesso em: 1 jul. 2024.
SOUZA, M. O. et al. A Prospective Study in Women: açaí (Euterpe oleracea Martius) dietary intake affects serum p-selectin, leptin, and visfatin levels. Nutricion Hospitalaria. 2021 Feb. 23; 38(1):121-127. English. doi: 10.20960/nh.03342. PMID: 33319583.Disponível em: https://pubmed.ncbi.nlm.nih.gov/33319583/. Acesso em: 1 jul. 2024.
SOUZA-MONTEIRO, J. R. et al. Antidepressant and Antiaging Effects of Açaí (Euterpe oleracea Mart.) in Mice. Oxidative Medicine and Cellular Longevity. 2019 July 24; 2019:3614960. doi: 10.1155/2019/3614960. PMID: 31428223; PMCID: PMC6681600. Disponível em: https://pubmed.ncbi.nlm.nih.gov/31428223/. Acesso em: 1 jul. 2024.
XAVIER, G. S. et al. Inhibitory Effect of Catechin-Rich Açaí Seed Extract on LPS-Stimulated RAW 264.7 Cells and Carrageenan-Induced Paw Edema. Foods. 2021 May 6; 10(5):1014. doi: 10.3390/foods10051014. PMID: 34066479; PMCID: PMC8148186. Disponível em: https://pubmed.ncbi.nlm.nih.gov/34066479/. Acesso em: 1 jul. 2024.
Este trabalho está licenciado sob uma licença Creative Commons Attribution-NonCommercial 4.0 International License.
Copyright (c) 2025 Daniel DE PAIVA, João Paulo Ferreira DE SOUZA, Marcelo FRANCHIN, Fernanda Flores NAVARRO